Zyprexa (Zyprexa)
General Health Treatment
Zyprexa (olanzapine) is an atypical antipsychotic medication used to treat schizophrenia and bipolar disorder. It helps to restore the balance of certain natural substances in the brain.
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Zyprexa Product Information
Zyprexa (olanzapine) is an atypical antipsychotic medication used for the treatment of schizophrenia and bipolar disorder. It can be used alone or in combination with other medications to manage manic or mixed episodes in bipolar I disorder. Additionally, it is used with fluoxetine for treatment-resistant depression and depressive episodes in bipolar I disorder.
By helping to restore the balance of dopamine and serotonin in the brain, Zyprexa can decrease hallucinations and help you think more clearly and positively about yourself, feel less agitated, and take a more active part in everyday life.
The exact mechanism of action of Zyprexa is not fully understood, but it is believed to work by blocking receptors for several neurotransmitters in the brain, particularly dopamine and serotonin. This helps to rebalance these chemicals, which can improve the symptoms of schizophrenia and bipolar disorder.
Take Zyprexa exactly as prescribed by your doctor. It is usually taken once a day, with or without food. For the orally disintegrating tablets (Zyprexa Zydis), make sure your hands are dry before handling the tablet. Place it on your tongue and allow it to dissolve; it can be swallowed with or without liquid.
Some improvement in symptoms may be noticed within the first 1-2 weeks of treatment, but it can take several weeks to a few months to experience the full therapeutic effects of Zyprexa. For acute agitation, the intramuscular injection can start working within 15-30 minutes.
The effects of Zyprexa typically last for about 24 hours.
Zyprexa Quick View
| Active Ingredient | Olanzapine |
|---|---|
| Manufacturer | Eli Lilly and Company |
| Type | Atypical antipsychotic |
| Onset | Oral forms of Zyprexa may begin to show effects within 1-2 weeks, with full effects seen in several weeks to months. The intramuscular injection has a rapid onset of 15-30 minutes. |
| Duration | The effects of a single dose of Zyprexa typically last for about 24 hours, which is why it is usually taken once a day. |
| Food Interaction | Zyprexa can be taken with or without food. Food does not significantly affect its absorption. |
| Alcohol | Alcohol may worsen side effects like sleepiness and hypotension. It is recommended to avoid alcohol while taking Zyprexa. |
| Prescription | Prescription only |
Zyprexa Side Effects
Common Side Effects
- Weight gain
- drowsiness
- dizziness
- constipation
- dry mouth
- increased appetite
- headache
- tremor
Uncommon Side Effects
- Increased salivation
- speech disorder
- forgetfulness
- pins and needles sensation
Rare Side Effects
- Neuroleptic Malignant Syndrome (NMS)
- Tardive Dyskinesia
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- Seizures
Important Warning: Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Zyprexa is not approved for the treatment of patients with dementia-related psychosis.
More Information About Zyprexa
Storage
Store Zyprexa at room temperature, between 68°F to 77°F (20°C to 25°C). Keep it away from light and moisture, and out of the reach of children.
Contraindications
Zyprexa is not for use in psychotic conditions related to dementia. It is also contraindicated in patients with a known hypersensitivity to olanzapine.
Drug Interactions
Zyprexa can interact with several other medications. Inform your doctor about all the medicines you are taking, including prescription and over-the-counter drugs, vitamins, and herbal supplements. Important interactions can occur with benzodiazepines, carbamazepine, fluvoxamine, and medications that lower blood pressure.
Zyprexa FAQs
No, you should not stop taking Zyprexa without consulting your doctor. Abruptly stopping the medication can cause withdrawal symptoms and a relapse of your condition.
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Yes, weight gain is a common side effect of Zyprexa. It is important to monitor your weight and discuss any concerns with your doctor. A healthy diet and regular exercise can help manage this side effect.
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Content last updated: 16 Apr 2026
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